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How Spindle ICSI Enhances IVF Success Rates and Embryo Quality

Jun 03, 2025

IVF Treatment

Female fertility specialist in white coat with stethoscope, Parency IVF's focus on Spindle ICSI and IVF success rates Female fertility specialist in white coat with stethoscope, Parency IVF's focus on Spindle ICSI and IVF success rates

he IVF journey can feel like an emotional rollercoaster, and for many, it’s especially difficult when the outcome doesn’t meet expectations. It’s completely understandable to feel discouraged after experiencing IVF failure. Sometimes, unseen factors during the fertilisation process are the root cause of these challenges. Spindle ICSI, an advanced IVF technique, is designed to address these hidden issues and offer a fresh opportunity for success. 

In this blog, we explained what Spindle ICSI is, how it works, and why it could be the solution that helps you move closer to your dream of becoming a parent.

What Is the Spindle in an Egg and Why Does It Matter?

The meiotic spindle is a structure within the egg that plays a crucial role during fertilisation. It helps separate the chromosomes before fertilisation occurs, ensuring the egg is ready to fuse with sperm. Damage to the spindle apparatus can lead to poor embryo quality, failed fertilisation, and increased chromosomal abnormalities. 

However, traditional ICSI doesn’t detect spindle damage, which is why some IVF cycles fail despite having healthy eggs and sperm. Understanding the role of the spindle can help identify hidden causes of fertilisation failure and improve the chances of successful IVF.

How Does Spindle ICSI Work?

Spindle ICSI works by using polarised light microscopy to detect the meiotic spindle in eggs before sperm injection. Here’s how it works:

  • Egg Retrieval: Eggs are collected from the ovaries as part of the regular IVF process.
  • Spindle Imaging Using Polarised Light: The Spindle View ICSI method uses specialised polarised light to visualise the spindle apparatus within the egg.
  • Precision Sperm Injection: Once the spindle is clearly visible, the sperm is injected with precision, avoiding any damage to the spindle.
  • Embryo Culture and Monitoring: The fertilised egg is cultured and monitored for embryo development.

By ensuring the meiotic spindle is intact, Spindle ICSI can significantly improve fertilisation success and embryo quality, offering better chances for women with poor egg quality or advanced maternal age.

Benefits of Spindle ICSI Over Traditional ICSI

Spindle ICSI offers several benefits over traditional ICSI, particularly for women over 35 and those with poor egg quality:

  • Improved Fertilisation Success: By ensuring that the egg’s spindle is intact, Spindle ICSI maximises fertilisation success, especially in cases of poor egg quality or repeated IVF failure.
  • Enhanced Embryo Quality: Spindle ICSI helps create better-quality embryos, increasing the likelihood of successful implantation and pregnancy.
  • Reduced Chromosomal Abnormalities: Detecting spindle damage and avoiding it during fertilisation reduces the risk of chromosomal abnormalities in the embryo, improving pregnancy outcomes.
  • Benefits for Older Women: For women over 35, Spindle ICSI can significantly improve IVF outcomes by addressing issues related to egg quality and diminished ovarian reserve.

In addition, the use of polarised light microscopy in Spindle ICSI improves precision sperm injection, which contributes to higher implantation rates and reduced abnormalities.

Who Should Consider Spindle ICSI?

Spindle ICSI is ideal for women who may experience fertilisation issues due to egg quality or other factors. This advanced technique is especially beneficial for:

  • Women over 35: As egg quality declines with age, Spindle ICSI can improve fertilisation rates and embryo quality.
  • IVF Failure Cases: Spindle ICSI offers a solution for those who have experienced failed IVF cycles due to unexplained fertilisation failure.
  • Poor Ovarian Reserve: Women with diminished ovarian reserve may benefit from this method to maximise egg quality.
  • Unexplained Fertilisation Failure: If traditional ICSI has failed despite healthy eggs and sperm, Spindle ICSI could help address hidden issues.

What to Expect After the Procedure

After Spindle ICSI, patients typically experience a similar recovery process to traditional IVF. The procedure takes a little longer than conventional ICSI due to the polarised light imaging, but the recovery is generally smooth. Here's what to expect:

  • Recovery Timeline: Most women recover within 1-2 days, with mild cramping or spotting, which is normal.
  • Embryo Development Updates: Regular updates on embryo development will be provided.
  • Embryo Freezing or Transfer: Depending on the quality of the embryos, they may be frozen for future use or transferred into the uterus once they reach a suitable developmental stage.

Patients can expect personalised care and ongoing monitoring throughout the process to ensure the best possible outcome.

In Conclusion: Moving Forward with Confidence

While the journey through IVF can be full of uncertainty and emotional challenges, advancements like Spindle ICSI offer renewed hope for many women. This innovative technique addresses hidden fertilisation issues, improving embryo quality and increasing the chances of a successful pregnancy. If you've faced repeated IVF failures, Spindle ICSI could be the key to unlocking your path to parenthood. With the right support, treatment, and perseverance, the dream of having a child can still become a reality.

Explore Spindle ICSI – Contact Parency IVF Hospital Today!

Thinking about improving your IVF outcomes? Ask about Spindle ICSI during your consultation with Parency IVF Hospital. Our expert team is dedicated to providing personalised care and exploring advanced fertility options that suit your needs. If you’ve struggled with fertilisation issues or have faced IVF failure, Spindle ICSI could significantly improve your chances. Schedule a consultation today to discover how this cutting-edge technique can help you achieve a successful pregnancy.

Frequently Asked Questions

What makes Spindle ICSI different from standard ICSI?

Spindle ICSI uses polarised light to detect and avoid damage to the meiotic spindle, which ensures better egg fertilisation and embryo quality compared to standard ICSI.

Is it suitable for all IVF patients?

While Spindle ICSI is beneficial for women with poor egg quality, IVF failure, or advanced maternal age, it is not necessary for everyone. Your doctor will assess whether it's the right option for you.

Can it improve chances after repeated IVF failure?

Yes, Spindle ICSI can be a game-changer for women who have experienced repeated IVF failure due to unexplained fertilisation issues.

Is the procedure safe and effective?

Spindle ICSI is both safe and effective, offering a higher chance of successful fertilisation and improved embryo quality.

Does it cost more than regular ICSI?

Yes, Spindle ICSI may incur additional costs due to the use of polarised light microscopy and the additional expertise required, but it can significantly improve your chances of success.
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